Bulletin of Pharmaceutical & Medicinal Research2959-91992958-65182022-10-133495710.58398/0005.000018articleAwais EjazSibgha UsmanNargis JavaidAl Ehsan Hospital, Mareer Chowke, Murree Road, RawalpindiUniversity of Health Sciences, PakistanCentral Institute of Family Medicine, PakistanDiabetes mellitus (DM) is an illness caused by either a relative or absolute loss of insulin; it is highly prevalent worldwide. The role of standard treatment guidelines (STGs) is fundamental to ensure positive treatment outcomes for type 2 diabetes mellitus (T2DM), as they promote rationality in prescriptions. This descriptive cross-sectional study aimed to determine healthcare providers’ perceptions of STGs for T2DM management, perceived barriers to T2DM management, and perceptions of the effectiveness of oral antidiabetics. Furthermore, the study also examined the associations of knowledge with the dose of antidiabetic agent, sector of employment and clinical experience. This study included 150 healthcare providers working in public and private tertiary care facilities in Islamabad. A relevant expert-verified questionnaire was employed in the study, and data were gathered via a convenient sampling technique. The results of the study revealed that 38.67% of the providers were from the public sector and that 61.33% of the providers were from the private sector. A total of 87.33% of the providers agreed that current antidiabetic drugs are effective, and 77.33% supported combination therapy; 64.00% reported that STGs are cost effective, and 94.67% underlined the importance of educational program treatment outcomes; 88.67% of the providers highlighted patient-related barriers, 80.67% highlighted limited guideline availability, and 80.00% highlighted a lack of prescriber awareness as major barriers in the implementation of STGs. Glimepiride by 82.00% of providers and metformin by 73.33% of providers were rated as most effective, whereas glibenclamide was the least preferred agent by 61.33% of providers. The level of knowledge varied, with sector showing a significant association (p = 0.001), whereas experience had no significant impact (p = 0.503). The study concluded that healthcare providers support the effectiveness of oral antidiabetics and the use of combination therapy, and the role of treatment guidelines in T2DM management, patient-related barriers, limited access to STGs, and discrepancies in knowledge across sectors remain major challenges in T2DM management.