Journal of Basic & Clinical Medical Sciences2959-92022959-92102022-09-1342859410.58398/0002.000029articleZara Husaain KhanFaculty of Community Medicine and Public Health, Liaquat University of Medical and Health Sciences, PakistanDepression is a public health problem affecting both males and females and is contributed by multiple social, demographic, and economic factors. However, scientific evidence comparing depressive symptoms among working women and homemakers in Pakistan remains limited. This community-based comparative study compared the proportion of depressive symptoms among working women and homemakers and determined their associations with sociodemographic characteristics. The study included 350 women aged 20–60 years residing in Hirabad, Hyderabad, Sindh, Pakistan, comprising 175 working women and 175 homemakers, and were selected using stratified random sampling. Data were collected using a structured questionnaire, and the Center for Epidemiologic Studies Depression Scale (CES-D) score and depressive symptoms were defined as a CES-D score > 23. The results showed that 137 (39.1%) participants had depressive symptoms, and the proportion of depressive symptoms was greater among homemakers than working women (42.9% vs. 35.4%); however, the difference was not statistically significant (χ² = 2.027, df = 1, p = 0.155). Depressive symptoms were significantly associated with age (p = 0.030), marital status (p = 0.014), educational attainment (p = 0.010), and socioeconomic status (p = 0.005), whereas no significant associations were observed with employment status or area of residence (p > 0.05). The study concluded that depressive symptoms were common among both working women and homemakers. Although a nonsignificant higher proportion of depressive symptoms was observed among homemakers. Sociodemographic factors, rather than employment status, were significantly associated with depressive symptoms in this study population.